a description of reference ranges for organic acids in urine samples from a pediatric population in iran
نویسندگان
چکیده
background: organic acids refer to a family of compounds that are intermediates in a variety of metabolic pathways. many organic acids are present in urine from clinically normal individuals. elevated levels of urine organic acids cause to the organic acidurias, disorders in which some metabolic pathways in organic acid metabolism are blocked. the present work identified major and minor urinary acidic metabolites in normal subjects, and their quantitative ranges in a pediatric population of iran. methods: two hundred and fifty-one healthy subjects, including 132 males and 119 females, from 2 days to 15 years of age were enrolled. urinary organic acids were extracted from urine with organic solvents and identified and quantified by gas chromatography-mass spectrometry. results: the results provide a foundation on which to check results for patients with potentially abnormal organic acidurias. by this method 98 organic acids were identified in a pediatric population of iran. conclusions: the present work identifies and quantifies major and minor urinary metabolites excreted by normal subjects. we also analyzed urine from 30 patients with organic acid metabolism abnormalities and compared the concentrations of specific organic acids with those from urines of normal individuals.
منابع مشابه
A Description of Reference Ranges for Organic Acids in Urine Samples from A Pediatric Population in Iran
Background: Organic acids refer to a family of compounds that are intermediates in a variety of metabolic pathways. Many organic acids are present in urine from clinically normal individuals. Elevated levels of urine organic acids cause to the organic acidurias, disorders in which some metabolic pathways in organic acid metabolism are blocked. The present work identified major and minor urinary...
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چکیده ندارد.
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AIM To establish age- and sex-specific reference intervals for essential amino acids in a healthy Turkish pediatric population. MATERIALS AND METHODS A total of 945 clinically healthy children (531 boys and 414 girls, ranging in age from birth to 14 years) were enrolled. Plasma and urine amino acids' concentrations were measured by high-performance liquid chromatography. RESULTS Concentrati...
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عنوان ژورنال:
reports of biochemistry and molecular biologyجلد ۶، شماره ۱، صفحات ۳۹-۴۹
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